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D.A. Uhlenheuer, L.G. Milroy, P. Neirynck and L. Brunsveld
Strong supramolecular control over protein self-assembly using a polyamine decorated β-cyclodextrin as synthetic recognition element
J. Mater. Chem., 21, 18919-18922, (2011)
DOI: 10.1039/C1JM12736E
Petkau - Milroy, K., Kaeser, A.G., Fischer, I., Brunsveld, L. & Schenning, A.P.H.J. (2011).
Pre- and postfunctionalized self-assembled pi-conjugated fluorescent organic nanoparticles for dual targeting.
Journal of the American Chemical Society, 133(42), 17063-17071, (2011).
Uhlenheuer, D. A.; Young, J. F.; Nguyen, H. D.; Scheepstra, M.; Brunsveld, L.
Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins
Chem. Commun., 47, 6798-6800, (2011)
DOI: 10.1039/C1CC11197C
Teunissen, S.F.; Rosing, H.; Dominguez Seoane, M.; Brunsveld, L.; Schellens, J.H.M.; Schinkel, A.H.; Beijnen, J.H.
Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques
Journal of Pharmaceutical and Biomedical Analysis
Volume 55, Issue 3, Pages 518-526, (2011)
doi:10.1016/j.jpba.2011.02.009
Möcklinghoff, S.; van Otterlo, W. A. L.; Rose, R.; Fuchs, S.; Zimmermann, T. J.; Dominguez Seoane, M.; Waldmann, H.; Ottmann, C.; Brunsveld, L.
Design and evaluation of fragment-like estrogen receptor tetrahydroisoquinoline ligands from a scaffold-detection approach
J. Med. Chem., 54 (7), pp 2005–2011
DOI: 10.1021/jm1011116
Sun, Y.; Jiang, L.; Schuermann, K. C.; Adriaens, W.; Zhang, L.; Boey, F. Y. C.; De Cola, L.; Brunsveld, L.; Chen, X.
Semiconductive One-Dimensional Self-Assembled Nanostructures Based on Oligopeptides with Pi-Conjugated Segments
Chemistry - A European Journal
Volume 17, Issue 17, pages 4746–4749, April 18, (2011)
DOI: 10.1002/chem.201003760
Göksel, H.; Wasserberg, D.; Möcklinghoff, S.; Vaz Araujo, B.; Brunsveld, L.
An on-bead assay for the identification of non-natural peptides targeting the Androgen Receptor–cofactor interaction
Bioorg. Med. Chem., 19, p. 306-311 (2011)
Müller, M.K.; Petkau, K.; Brunsveld L.
Protein assembly along a supramolecular wire
Chem. Comm., 47, p. 310-312 (2011)
Görmer, K.; Waldmann, H.; Brunsveld, L.
Lipidation of peptides and proteins
Comprehensive Natural Products II Chemistry and Biology; Mander, L., Lui, H.-W., Eds.;
Elsevier: Oxford, 2010; volume 5, pp.531–585.
Möcklinghoff, S.; Rose, R.; Carraz, M.; Visser, A.; Ottmann, C.; Brunsveld, L.
Synthesis and crystal structure of phosphorylated estrogen receptor ligand binding domain
ChemBioChem, 11, p. 2251-2254 (2010)
Phan, T.; Nguyen, H.D.; Göksel, H.; Möcklinghoff, S.; Brunsveld, L.
Phage display selection of miniprotein binders of the Estrogen Receptor
Chem. Comm. 46, p. 8207-8209 (2010)
Triola, G.; Gerauer, M.; Görmer, K.; Brunsveld, L.; Waldmann, H.
Solid phase synthesis of lipidated Ras peptide employing the Ellman sulfonamide linker.
Chem. Eur. J. 16, p. 9585-9591 (2010)
Chen, Y.X.; Koch, S.; Uhlenbrock, K.; Weise, K.; Das, D.; Brunsveld, L.; Wittinghofer, A.; Winter, R.; Triola, G.; Waldmann, H.
Synthesis of the Rheb and K-Ras4B GTPases
Angew. Chem. Int. Ed. 49, p. 6090-6095 (2010).
Uhlenheuer, D.A.; Petkau, K.; Brunsveld, L.
Combining supramolecular chemistry with biology.
Chem. Soc. Rev. 39, p. 2817-2826 (2010).
10.1039/b820283b
Rocks, O.; Gerauer, M.; Vartak, N.; Koch, S.; Huang, Z.P.; Pechlivanis, M.; Kuhlmann, J.; Brunsveld, L.; Chandra, A.; Ellinger, B.; Waldmann, H.; Bastiaens P.I.H.
The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins.
Cell 141, p. 458-471 (2010).
10.1016/j.cell.2010.04.007
Dekker, F.J.; Rocks, O.; Vartak, N.; Menninger, S.; Hedberg, C.; Balamurugan, R.; Wetzel, S.; Steffen Renner, S.; Gerauer, M.; Schölermann, B.; Rusch, M.; Kramer, J.W.; Rauh, D.; Coates, G.W.; Brunsveld, L.; Bastiaens, P.I.H.; Waldmann, H.
Small-molecule inhibition of APT1 affects Ras localization and signaling.
Nature Chem. Biol. 6, p. 449-456 (2010).
10.1038/nchembio.362
Nguyen, H.D.; Dang, D.T.; van Dongen, J.L.J.; Brunsveld L.
Supramolecular Induced Protein Dimerization with Cucurbit[8]uril
Angew. Chem. Int. Ed. 49, p. 895-898 (2010).
10.1002/anie.200904413
Young, J.F.; Nguyen, H.D.; Yang, L.; Huskens, J.; Jonkheijm, P.; Brunsveld L.
Strong and Reversible Monovalent Supramolecular Protein Immobilization
ChemBioChem 11, 180-183 (2010).
10.1002/cbic.200900599
Renner, S.; van Otterlo, W.; Dominguez Seoane, M.; Möcklinghoff, S.; Hofmann, B.; Wetzel, W.; Schuffenhauer, A.; Ertl, P.; Oprea, T.; Steinhilber, D.; Brunsveld, L.; Rauh, D.; Waldmann, H.
Bioactivity-Guided Mapping of and Navigation in Chemical Space by Means of Hierarchical Scaffold Trees
Nature Chem. Biol. 5, p. 585-592 (2009)
Mueller, M.K.; Brunsveld, L.
A Supramolecular Polymer as a Self-Assembling Polyvalent Scaffold
Angew. Chem. Int. Ed. 48, p. 2921-2924 (2009)
Brunsveld, L.
Elucidation of the Ras Cycle with Semi-Synthetic Proteins
Wiley-VCH, Eds. H. Waldmann, P. Janning.
in: Chemical Biology. Learning through Case Studies p. 175-188 (2009)
Gerauer, M.; Koch, S.; Waldmann, H.; Brunsveld, L.
Lipidated peptide synthesis
Wiley. Eds. T.P. Begley
Wiley encyclopedia of chemical biology 2, p. 520-530 (2009)
Weise, K.; Triola, G.; Brunsveld, L.; Waldmann, H.; Winter, R.
Influence of the Lipidation Motif on the Partitioning and Association of N-Ras in Model Membrane Subdomains
J. Am. Chem. Soc. 131, p. 1557–1564 (2009)
Brunsveld, L.; Waldmann, H.; Huster, D.
Membrane Binding of Lipidated Ras Peptides and Proteins – the Structural
Point of View
Biochimica et Biophysica Acta – Biomembranes 1788, p. 273-288 (2009)
Alexander, M.; Gerauer, M.; Pechlivanis, M.; Popkirova, B.; Dvorsky, R.; Brunsveld, L.; Waldmann, H.; Kuhlmann, J.
Mapping the isoprenoid-binding pocket of PDEdelta by a semisynthetic, photoactivatable N-Ras lipoprotein
ChemBioChem 10, p. 98-108 (2009)
Brunsveld, L.
Van molecuul tot cel
Inaugural Lecture ISBN 978-90-386-1752-7 (2009)
Uhlenheuer, D.A.; Wasserberg, D.; Nguyen, H.; Zhang, L.; Blum, C.; Subramaniam, V.; Brunsveld, L.
Modulation of Protein Dimerization by a Supramolecular Host-Guest System
Chem. Eur. J. 15, p. 8779-8790 (2009)
Vaz, B.; Möcklinghoff, S.; Folkertsma, S.; Lusher, S.; de Vlieg, J.; Brunsveld, L.
Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics
Chem. Comm. p. 5377-5379 (2009).
Carraz, M.; Zwart, W.; Phan, T.; Michalides, R.; Brunsveld, L.
Perturbation of Estrogen Receptor α localization with synthetic nona-arginine LXXLL-peptide coactivator binding inhibitors.
Chem. Biol. 16, p. 702-711 (2009)
Vaz, E.; Pommerantz, W.C.; Geyer, M.; Gellman, S.H.; Brunsveld, L.
Comparison of Design Strategies for Promotion of beta-peptide 14-helix Stability in Water
ChemBioChem 9, p. 2254-2259 (2008)
Vaz, B.; Brunsveld, L.
Stable Helical Peptoids via Covalent Side Chain to Side Chain Cyclization
Org. Biomol. Chem. 6, p. 2988-2994 (2008)
Guo, Z.; Wu, Y.; Das, D.; Delon, C.; Cramer, J.; Yu, S.; Thuns, S.; Lupilova, N.; Waldmann, H.; Goody, R.S.; Brunsveld, L.; Alexandrov, A.; Blankenfeldt, W.
Structures of Rab geranylgeranyl transferase:substrate/product complexes provide insights into evolution of protein prenylation
EMBO Journal 27, p. 2444 - 2456 (2008)
Triola, G.; Brunsveld, L.; Waldmann H.
Racemization-Free Synthesis of S-Alkylated Cysteines via Thiol-ene Reaction
J. Org. Chem. 73, p. 3646-3649 (2008).
Vaz, B.; Möcklinghoff, S.; Brunsveld, L.
Targeting the Nuclear Receptor – Cofactor Interaction
In Methods in principles in medicinal chemistry
Volume "Nuclear Receptors as Drug Targets" Eds: Eckhard Ottow and Hilmar Weinmann
p. 25-46 (2008)
Wu, Y.; Alexandrov, K.; Brunsveld, L
A high-throughput fluorometric assay for Rab geranylgeranyltransferase
Nature Protocols 2, p. 2704 - 2711 (2007).
Zhang, L.; Wu, Y.; Brunsveld, L.
A synthetic Supramolecular Construct Modulating Protein Assembly in Cells
Angew. Chem. Int. Ed. 46 p. 1798-1802 (2007)
Brunsveld, L.; Kuhlmann, J.; Alexandrov, K.; Wittinghofer, A.; Goods, R.S.; Waldmann, H.
Lipidated Ras and Rab peptides and proteins – synthesis, structure, and function
Angew. Chem. Int. Ed. Engl., 45 p. 6622-6646 (2006)
Brunsveld, L.; Kuhlmann, J.; Waldmann, H.
Synthesis of palmitoylated Ras-peptides and –proteins
Methods 40 p. 151-165 (2006)
Gelb, M.H.; Brunsveld, L.; Hrycyna, C.A.; Michaelis, S.; Tamanoi, F.; Van Voorhis, W.C.; Waldmann H.
Therapeutic intervention based on protein prenylation and associated modifications
Nature. Chem Biol. 2 p. 518-528 (2006)
Vaz, E.; Brunsveld, L.
Stable helical 3-peptides in water via covalent bridging of side chains.
Org. Lett., 8 p. 4199-4202 (2006)
Pylypenko, O.; Rak, A.; Durek, T.; Kushnir, S.; Dursina, B.; Brunsveld, L.; Watzke, A.; Waldmann, H.; Goody, R.S. and Alexandrov K.
Structure of doubly prenylated Ypt1: GDI complex and the mechanism of GDI mediated Rab: membrane interaction.
EMBO Journal, 25 p. 13-23 (2006)
Goody, R.S.; Durek, T.; Waldmann, H.; Brunsveld, L. and Alexandrov, K.
Application of protein semi-synthesis for the construction of functionalized posttranslationally modified RabGTPases
Methods in Enzymology, 403 p. 29-42 (2005)
Watzke. A.; Brunsveld, L.; Durek, T. Rak, A.; Goody, R.S. and Waldmann, H.
Chemical Biology of Protein Lipidation: Semi-Synthesis and Structure Elucidation of Prenylated RabGTPases
Org. Biomol. Chem., 3 p. 1157-1164 (2005)
Brunsveld, L.; Watzke, A.; Durek, T.; Alexandrov, K.; Goody, R.S. and Waldmann, H.
Synthesis of Functionalized Rab GTPases by a Combination of Solution- or Solid-Phase Lipopeptide Synthesis with Expressed Protein Ligation
Chem. Eur. J. 11 p. 2756-2772 (2005)
Marcos Ramos, A.; Meskers, S.C.J.; Beckers, E.H.A.; Prince, R.B.; Brunsveld, L.
and Janssen R.A.J.
Supramolecular control over donor-acceptor photoinduced charge separation
J. Am. Chem. Soc., 126 p. 9630-9644 (2004)
Rak, A.; Pylypenko, O.; Durek, T.; Watzke, A.; Kushnir, S.; Brunsveld, L.; Waldmann, H.; Goody, R.S. and Alexandrov, K.
Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase
Science 302(5646) p. 646-650 (2003)
Bosman, A.W.; Brunsveld, L.; Folmer, B.J.B.; Sijbesma, R.P. and Meijer, E.W.
Supramolecular polymers: From scientific curiosity to technological reality.
Macromolecular Symposia 201 p. 142-154 (2003)
Brunsveld, L.; Meijer, E.W.; Rowan A.E. and Nolte R.J.M.
Chiral discotics; expression and amplification of chirality
Topics in Stereochemistry 24 p. 373-423 (2003)
Brunsveld, L.; Vekemans, J.A.J.M.; Hirschberg, J.H.K.K.; Sijbesma R.P. and Meijer E.W.
Hierarchical formation of helical supramolecular polymers via stacking of hydrogen bonded pairs in water
Proc. Nat. Ac. Sci. U.S.A. 99 p. 4977-4982 (2002)
Brunsveld, L.; Lohmeijer, B.G.G.; Vekemans, J.A.J.M. and Meijer, E.W.
Amplification of chirality in helical supramolecular columns
J. Incl. Phen. Macrocyclic Chem. 41(1-4) p. 61-64 (2001)
Brunsveld, L.; Folmer, B.J.B.; Meijer, E.W. and Sijbesma, R.P.
Supramolecular polymers
Chem. Rev. 101 p. 4071-4097 (2001).
Prince, R.B.; Moore, J.S.; Brunsveld, L. and Meijer, E.W.
Cooperativity in the folding of helical m-phenylene ethynylene oligomers based upon the 'Sergeant and Soldiers' principle
Chem. Eur. J. 7 p. 4150-4154 (2001)
Brunsveld, L.; Meijer, E.W.; Prince, R.B. and Moore, J.S.
Self-assembly of folded m-phenylene ethynylene oligomers into helical columns
J. Am. Chem. Soc 123 p. 7978-7984 (2001)
van der Schoot, P.; Michels, M. A. J.; Brunsveld, L.; Sijbesma, R.P. and Ramzi, A.
Helical transition and growth of supramolecular assemblies of chiral discotic molecules
Langmuir, 16 p. 10076-10083 (2000)
Brunsveld, L.; Lohmeijer, B.G.G.; Vekemans, J.A.J.M. and Meijer, E.W.
Chirality amplification in dynamic helical columns in water
Chem. Commun., p. 2305-2306 (2000)
Hirschberg, J.H.K.K.; Brunsveld, L.; Ramzi, A.; Vekemans, J.A.J.M.; Sijbesma, R.P. and Meijer, E.W.
Helical self-assembled polymers via cooperative stacking of hydrogen-bonded pairs
Nature, 407(6801) p. 167-170 (2000)
Brunsveld, L.; Folmer, B.J.B. and Meijer, E.W.
Supramolecular polymers
MRS Bulletin, 25 p. 49-53 (2000)
Brunsveld, L.; Schenning, A.P.H.J.; Broeren, M.A.C.; Janssen, H.M.; Vekemans, J.A.J.M. and Meijer, E.W.
Chiral amplification in columns of self-assembled N,N',N''-tris((S)-3,7-dimethyloctyl)benzene-1,3,5-tricarboxamide in dilute solution
Chem. Lett., p. 292-293 (2000)
Prince, R.B.; Brunsveld, L.; Meijer, E.W. and Moore, J.S.
Twist sense bias induced by chiral side chains in helically-folded oligomers
Angew. Chem. Int. Ed. Engl., 39 p. 228-230 (2000)
Brunsveld, L.; Prince, R.B.; Meijer, E.W. and Moore, J.S.
Conformational ordering of apolar chiral m-phenylene ethynylene oligomers
Org. Lett., 2 p. 1525-1528 (2000)
Brunsveld, L.; Zhang, H.; Glasbeek, M.; Vekemans, J.A.J.M. and Meijer, E.W.
Hierarchical growth of chiral self-assembled structures in protic media
J. Am. Chem. Soc., 122 p. 6175-6182 (2000)
Brunsveld, L.; Vekemans, J.A.J.M.; Janssen, H.M. and Meijer, E.W.
The influence of lithium perchlorate on discotic liquid crystals and the ion conduction of their mixtures
Mol. Cryst. Liq. Cryst., 331 p. 449 - 456 (1999)
Sijbesma, R.P.; Beijer, F.H.; Brunsveld, L.; Folmer, B.J.B.; Hirschberg, J.H.K.K.; Lange, R.F.M.; Lowe J.K.L. and Meijer E.W.
Reversible polymers formed from self-complementary monomers using quadruple hydrogen-bonding
Science, 278(5343) p. 1601-1604 (1997)